Search Keyword : Diabetes Mellitus


Disease List

CUI Disease
C0011849 Diabetes Mellitus
C0085207 Diabetes, Gestational
C0011860 Diabetes Mellitus, Non-Insulin-Dependent
C0011854 Diabetes Mellitus, Insulin-Dependent
C0034818 Insulin Receptor
C0271695 Pineal hyperplasia AND diabetes mellitus syndrome
C0155733 Atherosclerosis of aorta
 others no cui disease

Disease Information

CUI  C0011849
Disease Name  Diabetes Mellitus
Synonymous  Diabetes mellitus, NOS
Diabetes mellitus NOS
diabetes
Diabetes NOS
DM - Diabetes mellitus
Diabetes mellitus (disorder)
Description  A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

heterogeneous group of disorders that share glucose intolerance in common.

Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Adipocytes secrete a unique signalling molecule, which was named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.

RAEB: Relative or absolute lack of insulin, leading to uncontrolled carbohydrate metabolism. 


Gene Information

CUI Disease Gene Symbol Table Name
 C0011849 Diabetes mellitus, type II, 125853 (3) AKT2  MorbidMap 
 C0011849 {Diabetes mellitus, non-insulin-dependent, susceptibility to}, 125853 (3) ENPP1  MorbidMap 
 C0011849 {Diabetes mellitus, type 1, susceptibility to}, 222100 (3) OAS1  MorbidMap 
 C0011849 {Diabetes mellitus, type 2, susceptibility to}, 125853 (3) TCF7L2  MorbidMap 
 C0011849 {Diabetes mellitus, type I, susceptibility to}, 222100 (3) FOXP3  MorbidMap 
 C0011849 {Diabetes mellitus, type II, susceptibility to}, 125853 (3) PDX1  MorbidMap 
 C0011849 diabetes mellitus GC  GAD 
 C0011849 Diabetes mellitus GATA1  GAD 
 C0011849 diabetes mellitus CTLA4  GAD 
 C0011849 diabetes mellitus CETP  GAD 
 C0011849 diabetes mellitus TNF  GAD 
 C0011849 diabetes mellitus SOD2  GAD 
 C0011849 Diabetes Mellitus NAT2  GAD 
 C0011849 diabetes mellitus LDLR  GAD 
 C0011849 diabetes mellitus INS  GAD 
 C0011849 Diabetes Mellitus CYP2A6  GAD 
 C0011849 diabetes mellitus MTHFR  GAD 
 C0011849 diabetes mellitus glycogen synthase  GAD 
 C0011849 diabetes mellitus HLA  GAD 
 C0011849 diabetes mellitus type I HLA  GAD 
 C0011849 diabetes mellitus HLA  GAD 
 C0011849 diabetes mellitus HLA  GAD 
 C0011849 diabetes mellitus HLA  GAD 
 C0011849 diabetes mellitus paraoxonase  GAD 

SNP Information

CUI OMIM ID OMIM Variant ID Disease Gene Symbol Changes SNP ID Table Name
 C0011849 138033 0001 DIABETES MELLITUS, TYPE II GCGR  GLY40SER  OMIM_Variant 
 C0011849 138430 0001 DIABETES MELLITUS, TYPE II GPD2  PHE635SER  rs28932770  OMIM_Variant 
 C0011849 142410 0008 DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO TCF1  GLY319SER  OMIM_Variant 
 C0011849 147545 0001 DIABETES MELLITUS, TYPE II IRS1  3-BP DEL GLY723  OMIM_Variant 
 C0011849 147545 0003 DIABETES MELLITUS, TYPE II IRS1  THR608ARG  OMIM_Variant 
 C0011849 164350 0002 DIABETES MELLITUS, TYPE 1, SUSCEPTIBILITY TO OAS1  SER162GLY  OMIM_Variant 
 C0011849 164731 0001 DIABETES MELLITUS, TYPE II AKT2  ARG274HIS  OMIM_Variant 
 C0011849 600733 0002 DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO IPF1  ASP76ASN  OMIM_Variant 
 C0011849 600733 0003 DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO IPF1  GLN59LEU  OMIM_Variant 
 C0011849 600733 0004 DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO IPF1  3-BP INS 243CCG  OMIM_Variant 
 C0011849 600733 0005 DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO IPF1  CYS18ARG  OMIM_Variant 
 C0011849 600733 0006 DIABETES MELLITUS, TYPE II, SUSCEPTIBILITY TO IPF1  ARG197HIS  OMIM_Variant 
 C0011849 601487 0002 DIABETES MELLITUS, TYPE II, MODIFIER OF INTIMAL MEDIAL THICKNESS OF INTERNAL CAROTID ARTERY, MODIFIER OF, PPARG2  PRO12ALA  rs17241090  OMIM_Variant 
 C0011849 601724 0001 DIABETES MELLITUS, TYPE II NEUROD1  ARG111LEU  OMIM_Variant